教育工作经历

2016年9月-2020年6月，四川大学生命科学学院，生物科学，学士

2020年9月-2025年6月，中山大学附属第三医院，基础医学，博士，导师：李明强

2025年8月-至今，福州大学医学院，副教授

科研简介

致力于通过创新性的智能工程化平台，突破实体瘤过继细胞疗法在扩增效率、体内持久性和肿瘤浸润能力等方面的关键瓶颈。研究以膜融合脂质体技术为核心，构建了“胞内-胞外协同工程化”体系，实现免疫细胞在胞质递送与膜表面修饰上的时空协同调控，推动过继细胞疗法从单一功能强化向系统免疫重塑转变。

学术任（兼）职

科研项目

可视化膜融合纳米药物对肺部炎症及免疫稳态调控研究，国家重点研发计划，2024-2027，参与

基于功能化生物材料的体内工程化T细胞用于实体瘤治疗的研究，国家重点研发计划，2025-2028，参与

代表性论文

（1）Chunxiong Zheng^#, Qingguo Zhong^#, Wantong Song, Ke Yi, Huimin Kong, Haixia Wang, Yu Tao*, Mingqiang Li*, Xuesi Chen*. Membrane-Fusion-Mediated Multiplex Engineering of Tumor Cell Surface Glycans for Enhanced NK Cell Therapy. Advanced Materials, 2023, 35(14): 2206989.

（2）Chunxiong Zhen^g#, Qingguo Zhong^#, Ke Yi, Huimin Kong, Fangfang Cao, Chenya Zhuo, Yanteng Xu, Run Shi, Enguo Ju, Wantong Song, Yu Tao*, Xiaoyuan Chen*, Mingqiang Li*. Anti–phagocytosis-blocking repolarization-resistant membrane-fusogenic liposome (ARMFUL) for adoptive cell immunotherapy. Science Advances, 2023, 9(32): eadh2413.

（3）Qingguo Zhong^#, Chunxiong Zheng^#, Ke Yi, Rachel L. Mintz,b Shixian Lv, Yu Tao, Mingqiang Li*. Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles in vivo. Biomaterials Science, 2023.

（4）Dongmei Xie#, Qingguo Zhong^#, Xiaochun Xu, Yuanlong Li, Simin Chen, Mingqiang Li*, Chaoquan Peng*. Alpha lipoic acid-loaded electrospun fibrous patch films protect heart in acute myocardial infarction mice by inhibiting oxidative stress. International Journal of Pharmaceutics, 2023, 632: 122581.

（5）Huimin Kong^#, Siqing Wang^#, Chenya Zhuo^#, Qingguo Zhong^#, Yanteng Xu, Yeh-Hsing Lao, Shixian Lv, Xi Xie, Qing Yuan*, Kai Li*, Yu Tao*, Mingqiang Li*, Nanovescicles integrating PD-1-mediated targeting and CRISPR/Cas9-based CD47 editing for dual immune checkpoint blockade, Journal of Controlled Release, 2025, 114480, 0168-3659.

（6）Chunxiong Zheng^#, Ke Yi^#, Yongkang Du, Qingguo Zhong, Huimin Kong, Haixia Wang, Enguo Ju, Yeh-Hsing Lao, Xi Xie, Haochen Yao*, Yu Tao*, Mingqiang Li*. Immuno-Packed T-Cell-Fusogenic Liposome Empowers Adoptive T Cell Therapy for Solid Tumor Treatment.” Advanced Materials, 2025: e10842.

（7）Yuqin Wang, Quanmin Wang, Qingguo Zhong, Yanteng Xu, Chunxiong Zheng, Mingqiang Li*, Yu Tao*, Enguo Ju*, Immunomodulatory microneedle patch for enhanced Ferroptosis and immunogenic cell death in postoperative tumor therapy, Journal of Controlled Release, 2024, 766-776, 0168-3659.

（8）Yanteng Xu^#, Yixin Zhang^#, Hao Tian^#, Qingguo Zhong, Ke Yi, Fenfang Li, Tiantian Xue, Haixia Wang, Yeh-Hsing Lao, Yingying Xu, Yinxiong Li, Ling Long, Kai Li*, Yu Tao*, Mingqiang Li*, Smart Microneedle Arrays Integrating Cell-Free Therapy and Nanocatalysis to Treat Liver. Advanced. Science, 11: 2470187.

（9）Zheng Liu^#, Bolong Liu^#, Youqiang Fang^#, Qingguo Zhong, Yiling Zhong*, Yeh-Hsing Lao, Shixian Lv, Xi Xie, Yu Tao*, Xiangfu Zhou*, Mingqiang Li*, Engineering natural killer cells for cancer immunotherapy, Cell Reports Physical Science, 2025, 102681, 2666-3864.

（10）Ke Yi, Huimin Kong, Chunxiong Zheng, Chenya Zhuo, Yuanyuan Jin, Qingguo Zhong, Rachel L. Mintz, Enguo Ju, Haixia Wang, Shixian Lv, Yeh-Hsing Lao, Yu Tao, Mingqiang Li*, A LIGHTFUL nanomedicine overcomes EGFR-mediated drug resistance for enhanced tyrosine-kinase-inhibitor-based hepatocellular carcinoma therapy, Biomaterials, 2023, 122349, 0142-9612.

（11）Huimin Kong^#, Chenya Zhuo^#, Ke Yi, Chunxiong Zheng, Rachel L. Mintz, Yeh-Hsing Lao, Qingguo Zhong, Enguo Ju, Haixia Wang, Dan Shao, Haihua Xiao*, Yu Tao*, Mingqiang Li*, Hepatocyte-confined CRISPR/Cas9-based nanocleaver precisely eliminates viral DNA for efficient and safe treatment of hepatitis B virus infection, Nano Today, 2023, 102040, 1748-0132.

（12）Xiaodie Chen, Jiabin Zhang, Tong Lin, Feng Zhou, Fenfang Li, Tiantian Xue, Qingguo Zhong, Weijen Lee, Guipan Chen, Haixia Wang, Enguo Ju, Mingqiang Li*, Yu Tao*, Bioactive Decellularized Extracellular Matrix Platform Integrating Multifunctional Nanozymes and Cell-Laden Microgels for Acute Liver Failure Treatment, ACS Nano 2025 19 (7), 6890-6910.

（13）Keying Chen, Chunxiong Zheng, Yunjuan Lv, Pengkai Zhao, Tong Lin, Yanteng Xu, Huimin Kong, Ke Yi, Qingguo Zhong, Mingqiang Li*, Yu Tao*, Haixia Wang*, Complement opsonized protein corona activated by precoated immunoglobulin enables neutrophil-hitchhiking for rapid and enhanced drug delivery for acute liver failure recovery, Nano Today, 2024, 102512, 1748-0132.

（14）Madi Sun, Peiyu Chen, Kai Xiao, Xiang Zhu, Zhibin Zhao, Chenyang Guo, Xuan He, Tongfei Shi, Qingguo Zhong, Yong Jia, Yu Tao, Mingqiang Li*, Kam W. Leong*, Dan Shao*, Circulating Cell-Free DNAs as a Biomarker and Therapeutic Target for Acetaminophen-Induced Liver Injury. Advanced. Science, 2023, 10, 2206789.