教育工作经历
2011-09 至 2014-07, 南方医科大学, 麻醉学, 博士
2004-09 至 2007-07, 福建医科大学, 麻醉学, 硕士
1994-09 至 1999-07, 福建医科大学, 麻醉学, 学士
科研简介
以第一作者(含共同)及通讯作者(含共同)发表SCI论文10余篇,主持福建省自然科学基金面上项目、福建省科技厅医学创新项目A类等省厅级以上课题4项
科研项目
2024-11 至 2027-11, 福建省自然科学基金,2024J011647,骶丛阻滞改善微循环介导VEGF/PI3K/Akt信号通路促进M2巨噬细胞极化加速糖尿病足溃疡愈合的作用机制研究,主持;
2024-01 至 2026-12,福建省科技厅医学创新课题A类,2023CXA007,骶丛阻滞通过抑制ANGII-NOX信号通路改善内皮细胞线粒体功能促进糖尿病足溃疡血管再生的机制研究,主持;
2022-01-01 至 2025-12-31,国家自然科学基金委员会, 面上项目, 82171186, 利多卡因通过NR2B/CREB/BDNF信号轴调控细胞自噬在老年脑认知功能损害中的作用与机制研究, 在研,
2020-11 至 2023-09, 福建省自然科学基金, 2020J011078, 高糖通过mTOR/p53/PINK1通路调控线粒体自噬在围术期神经认知障碍中的作用及机制研究, 结题, 主持;
2020-08 至 2023-07, 福建省教育厅, 重大教改项目, FBJG20200022, 基于虚拟现实与触觉反馈技术的椎管内穿刺教学平台的研发与应用, 在研,主持;
2022-04 至 2023-06,福建省海峡医药卫生交流协会, 探索性科研项目, 2020-HYH-30, 超声引导骶旁筋膜间隙阻滞在下肢闭塞性脉管炎中的应用, 在研,主持;
2019-09 至 2022-08,福建省卫生健康委员会, 中青年骨干人才培养项目, 2019-ZQN-1, 基于mTOR信号通路调控自噬研究糖尿病加重术后认知功能障碍的机制, 结题, 主持
代表性论文
1、Lateral parasacral ischial plane block: A novel approach to the sacralplexus in the supine position, Journal of Clinical Anesthesia , 2023(第一作者);
2、Minimum local anesthetic dose of ropivacaine in real-time ultrasound-guided intraspinalanesthesia for lower extremity surgery: a randomized controlled trial, ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8(14)(第一作者);
3、Minimum Local Anesthetic Dose of Ropivacaine in Cesarean Section for Real-Time Ultrasound-Guided Spinal Anesthesia Using 24-Gauge versus 26-Gauge Needles Based on Fluid Simulation Technology: A Randomized Controlled Trial, Drug Design, Development and Therapy.2024 Oct 1:18:4401-4412(通讯作者).
4、A proof-of-concept study of ultrasound-guided continuous parasacral ischial plane block for postoperative pain control in patients undergoing total knee arthroplasty. Journal of Orthopaedic Surgery and Research. 2024 Jun 8;19(1):339(第一作者).
5、Gut microbiota-derived 3-indoleacetic acid confers a protection against sepsis-associated encephalopathy through microglial aryl hydrocarbon receptors. [J].Experimental neurology, 2024, 384 115055.(共同通讯作者).
6、Research and application of a teaching platform for combined spinal-epidural anesthesia based on virtual reality and haptic feedback technology. [J]. BMC medical education,2023,23(1):794-794.(第一作者).
7、Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose. Neuromolecular Med. 2023;25(3):415-425(通讯作者).
8、A proof-of-concept study of ultrasound-guided continuous parasacral ischial plane block for postoperative pain control in patients undergoing total knee arthroplasty [J]. Journal of Orthopaedic Surgery and Research, 2024, 19 (1):339-339. (共同第一作者)
9、Comparison between butorphanol and nalbuphine for alleviation of catheter-related bladder discomfort and emergence agitation in patients undergoing open spinal surgery: a randomized clinical trial. Ann Med. 2025 Dec;57(1):2534853.(通讯作者).
10、Utility of novel composite index in predicting the prognosis of total neoadjuvant therapy for locally advanced rectal cancer: A multicenter real-world cohort study. Dig Liver Dis. 2025 Aug 26:S1590-8658(25)00990-9. (共同通讯作者)